Wall Street sold off on Tuesday as disappointing corporate reports gave a sour tone to the start of earnings season and investors digested possible changing dynamics for the upcoming US elections.
Alcoa shares tumbled 11.4 percent after the metals company's quarterly profit missed estimates and it lowered its revenue forecast.
The Dow Jones industrial average fell 200.38 points, or 1.09 percent, to 18,128.66, the S&P 500 lost 26.93 points, or 1.24 percent, to 2,136.73 and the Nasdaq Composite dropped 81.89 points, or 1.54 percent, to 5,246.79.
All 11 major S&P sectors ended negative. Healthcare , one of the sectors most sensitive to the outcome of the elections, led declines. The group slumped 2.5 percent, with fallout from Illumina's report also weighing.
Another healthcare company, St Jude Medical , fell 3.5 percent after saying it would recall some implanted heart devices due to risk of premature battery depletion. Abbott Laboratories , which has agreed to buy St Jude, dropped 5.4 percent.
Energy shares fell 1.2 percent as oil prices retreated from one-year highs.
For the year, the S&P 500 is up 4.5 percent.
About 6.7 billion shares changed hands on US exchanges, slightly below the 6.8 billion daily average for the past 20 trading days, according to Thomson Reuters data.
Declining issues outnumbered advancing ones on the NYSE by a 6.96-to-1 ratio; on Nasdaq, a 5.10-to-1 ratio favoured decliners.
The S&P 500 posted 4 new 52-week highs and 4 lows; the Nasdaq Composite recorded 46 new highs and 59 lows.
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